10 Best Fractional CO2 Laser Machines for Sale in 2025

In 2025, fractional CO2 laser machines are revolutionizing skin rejuvenation and medical aesthetics. These devices are gaining popularity for their ability to deliver impressive results with minimal downtime. Patients love the shorter recovery periods and noticeable improvements in skin elasticity. For instance, many report feeling rejuvenated and receiving compliments on their complexion after treatments.

Why are these machines in such high demand? Non-invasive procedures are becoming the go-to choice for patients. Plus, their versatility extends beyond skincare to areas like dermatology and even dentistry. If you’re searching for the best fractional CO2 laser machine for sale, this guide will help you make an informed decision.

Key Takeaways

Fractional CO2 lasers help improve skin with little recovery time.
Pick a machine based on its use, like scar fixing or skin smoothing.
Choose machines that are easy to use and adjust, especially for new users.
Check the machine’s power; stronger ones often give better results.
Think about upkeep and warranties to avoid surprise expenses later.
Compare costs and features to fit your clinic’s budget and needs.
Safety tools, like cooling systems, keep patients and workers safe.
A good machine can make patients happier and boost clinic earnings.

Top 10 Fractional CO2 Laser Machines in 2025

1.FotroMed Fractional CO2 Laser Machine

Key Features

Looking for a reliable option for laser resurfacing? The FotroMed Fractional CO2 Laser Machine offers advanced fractional technology that targets specific skin concerns like acne scars, pigmentation, and fine lines. Its customizable settings let you tailor treatments to meet your clients’ unique needs. Plus, it ensures minimal discomfort and quick recovery, making it a favorite for skin resurfacing treatments. The user-friendly interface simplifies operation, even for beginners.

Technical Specifications

This machine is built to last, with a working life of 20,000 hours. It delivers a high power of 40W, making it suitable for both skin resurfacing and gynecological treatments. You can rely on its FDA and CE certifications for safety and effectiveness. It’s also refillable, which adds to its cost-effectiveness.

Applications

The FotroMed Fractional CO2 Laser Machine is perfect for addressing acne scars, wrinkles, and sun-damaged skin. It’s also effective for surgical cutting and gynecological procedures. Whether you’re treating fine lines or deeper scars, this machine delivers visible results that your clients will love.

Pros

FDA-approved for safety and effectiveness.
Customizable settings for precise treatments.
Minimal downtime with faster recovery.
Long lifespan and refillable design for cost efficiency.

2.FotroMed CO₂ CeloLaser Pro

Key Features

The CO₂ CeloLaser Pro combines precision and versatility. It uses fractional lasers to create micro-holes in the skin, triggering natural healing. This process improves skin texture and reduces pigmentation. With multiple treatment modes and adjustable spot sizes, you can handle everything from acne scars to wrinkle reduction.

Technical Specifications

This machine features an RF-excited CO2 laser with a wavelength of 10.6μm. It offers a peak power of up to 60W and includes six treatment tips for different applications. The 12.1-inch LCD screen makes it easy to adjust settings. Its compact design and high energy transmittance ensure efficient and effective treatments.

Applications

The CO₂ CeloLaser Pro is ideal for skin resurfacing, scar reduction, and wrinkle treatments. It’s also suitable for dermatology and plastic surgery. If you’re looking to expand your clinic’s offerings, this machine is a versatile choice.

Pros

High precision with adjustable spot sizes.
Rapid results with minimal side effects.
Versatile for both facial and body treatments.
User-friendly interface for seamless operation.

3.FotroMed CO₂ CeloLaser Compact

Key Features

Need a powerful machine but short on space? The CO₂ CeloLaser Compact is your answer. It delivers the same advanced fractional technology as larger models but in a space-saving design. Its precision fractional lasers ensure targeted treatments with minimal downtime.

Technical Specifications

This compact device operates with a sealed-off DC CO2 laser and offers an output energy range of 1 to 60W. It features a 7-joint articulate arm for optical transmission and a closed internal water cooling system. The large touch display makes it easy to navigate settings.

Applications

The CO₂ CeloLaser Compact excels in skin resurfacing, wrinkle reduction, and gynecological health. It’s a great option for clinics that want high-performance equipment without sacrificing space.

Pros

Compact design perfect for smaller clinics.
Advanced technology for precise treatments.
Versatile applications, including gynecological health.
Minimal downtime with faster recovery.

4.Lumenis AcuPulse

Key Features

The Lumenis AcuPulse stands out with its advanced fractional technology, offering precision and minimal downtime. You can customize treatments to meet individual patient needs, making it a versatile choice for clinics. Its safety features, like adjustable energy levels and depth of penetration, ensure patient comfort and reduce complications.

This machine also excels in reducing discomfort during procedures. By creating micro-injuries, it minimizes pain compared to traditional methods. Patients love the shorter recovery time, allowing them to resume daily activities quickly. With 11 built-in treatment modes and an intuitive user interface, you’ll find it easy to set up and deliver effective treatments.

Technical Specifications

The Lumenis AcuPulse features an exceptional ablation/coagulation ratio, achieving the desired treatment depth with a single pulse. Its 11 treatment modes provide full parameter control, ensuring maximum versatility. The intuitive user interface simplifies operation, making it ideal for both new and experienced practitioners.

Applications

This machine is perfect for laser resurfacing, addressing acne scars, and improving skin texture. It’s also effective for treating wrinkles and pigmentation issues. Whether you’re performing deep or superficial treatments, the Lumenis AcuPulse delivers consistent results that your clients will appreciate.

Pros

Advanced fractional technology for precision.
Customizable treatments for various skin concerns.
Reduced discomfort and shorter recovery times.
Easy-to-use interface with 11 treatment modes.

A clinical study highlighted the effectiveness of the Lumenis AcuPulse. Participants with photodamaged skin reported significant improvements in wrinkle and pigment scores, with over 65% expressing satisfaction at the 3-month follow-up.

5.Cynosure SmartSkin+

Key Features

The Cynosure SmartSkin+ offers unmatched efficiency and customization. You can adjust settings to target specific skin concerns, ensuring personalized treatments. This machine delivers fast procedures, completing a full-face treatment in just 20 minutes. Patients benefit from minimal downtime, typically recovering within 5-7 days.

Another standout feature is its cost-effectiveness. Unlike many competitors, the SmartSkin+ doesn’t require consumables, reducing operational costs. High patient satisfaction rates make it a reliable choice for clinics aiming to enhance their offerings.

Technical Specifications

Feature	Cynosure SmartSkin+	Competitors
Customizable settings	Yes	Limited
Efficiency	High	Varies
Minimal downtime	5-7 days	Longer
Fast procedure time	20 min/face	Slower
No consumables required	Yes	Often required
High patient satisfaction	Yes	Varies

Applications

The SmartSkin+ excels in skin resurfacing, wrinkle reduction, and treating acne scars. It’s also effective for improving skin tone and texture. If you’re looking for a machine that combines speed and precision, this is a great option.

Pros

Highly efficient with fast procedure times.
Minimal downtime for quicker recovery.
No consumables required, reducing costs.
Customizable settings for tailored treatments.

6.Alma Pixel CO2

Key Features

The Alma Pixel CO2 combines fractional lasers with cutting-edge technology to deliver exceptional results. It’s designed for precision, creating micro-injuries that stimulate collagen production and improve skin elasticity. This machine offers multiple treatment modes, allowing you to address a wide range of skin concerns.

Its user-friendly interface ensures smooth operation, even for beginners. Patients love the visible improvements in skin texture and reduced appearance of acne scars. With minimal downtime, it’s a popular choice for clinics aiming to provide effective treatments without long recovery periods.

Technical Specifications

The Alma Pixel CO2 operates with a wavelength of 10.6μm, delivering consistent energy output for precise treatments. It features multiple handpieces for different applications, enhancing its versatility. The compact design makes it suitable for clinics with limited space.

Applications

This machine is ideal for skin resurfacing, treating acne scars, and reducing wrinkles. It’s also effective for improving skin tone and elasticity. Whether you’re targeting fine lines or deeper scars, the Alma Pixel CO2 delivers reliable results.

Pros

Advanced fractional lasers for precise treatments.
Multiple treatment modes for versatility.
Compact design suitable for smaller clinics.
Minimal downtime with faster recovery.

7.Syneron CO2RE

Key Features

The Syneron CO2RE is a versatile fractional CO2 laser machine designed to handle a wide range of skin concerns. It offers dual laser resurfacing modes, allowing you to treat both superficial and deep layers of the skin in a single session. This dual-mode capability makes it a favorite for clinics aiming to deliver comprehensive treatments. The machine also features customizable energy levels, giving you precise control over the intensity of each procedure.

Another standout feature is its ability to perform fractional treatments with minimal downtime. Patients appreciate the quick recovery, which allows them to return to their daily routines faster. The intuitive interface ensures smooth operation, even for practitioners new to fractional lasers.

Technical Specifications

The Syneron CO2RE operates with a CO2 laser wavelength of 10.6μm, delivering consistent energy output for precise treatments. It offers multiple scanning patterns and adjustable spot sizes, making it adaptable to various skin types and conditions. The device also includes a built-in cooling system to enhance patient comfort during procedures.

Applications

This machine excels in treating acne scars, wrinkles, and uneven skin texture. It’s also effective for addressing pigmentation issues and sun damage. Whether you’re performing deep resurfacing or targeting superficial imperfections, the Syneron CO2RE delivers reliable results every time.

Pros

Dual laser modes for versatile treatments.
Minimal downtime with faster recovery.
Customizable energy levels for precision.
User-friendly interface for seamless operation.

8.ActiveFX with UltraPulse Encore

Key Features

The ActiveFX with UltraPulse Encore is a game-changer in fractional ablative skin resurfacing. It’s FDA-approved and specifically designed to target superficial signs of aging, such as brown spots and sun damage. This machine uses a unique protocol that leaves intact tissue bridges between treated areas, promoting faster healing and reducing thermal damage.

One of its standout features is the Cool Scan technology, which applies random laser spots instead of a sequential pattern. This approach prevents overheating and enhances thermal relaxation, ensuring a more comfortable experience for your patients. The smaller spot size of 1300 mm minimizes post-procedure redness, making it a top choice for clinics focused on patient satisfaction.

Technical Specifications

The ActiveFX operates with a fractional CO2 laser and features a wavelength of 10.6μm. It includes advanced Cool Scan technology and offers customizable energy settings for tailored treatments. The device is compact yet powerful, making it suitable for clinics of all sizes.

Applications

This machine is perfect for fractional ablative skin resurfacing. It effectively addresses superficial aging signs, including brown spots and sun damage. By promoting the peeling of damaged skin, it reveals a healthier, rejuvenated layer underneath.

Pros

FDA-approved for safety and effectiveness.
Cool Scan technology prevents overheating.
Faster healing with reduced thermal damage.
Compact design suitable for any clinic.

9.Solta Medical Fraxel re:pair

Key Features

The Solta Medical Fraxel re:pair is a trusted name in fractional lasers. It’s designed to deliver precise treatments that stimulate collagen production and improve skin elasticity. This machine offers multiple treatment modes, allowing you to customize procedures based on your clients’ needs.

Patients love the noticeable results, especially in reducing acne scars and fine lines. The device’s advanced technology ensures minimal downtime, making it a popular choice for busy individuals seeking effective skin resurfacing treatments.

Technical Specifications

The Fraxel re:pair operates with a fractional CO2 laser and features a wavelength of 10.6μm. It includes multiple handpieces for different applications, enhancing its versatility. The compact design and intuitive interface make it easy to use, even in smaller clinics.

Applications

Fine lines and wrinkles
Brown spots from sun exposure or aging
Hyperpigmentation
Scarring
Uneven skin texture and tone

Pros

Advanced fractional lasers for precise treatments.
Multiple treatment modes for versatility.
Minimal downtime with faster recovery.
Compact and user-friendly design.

10.DEKA SmartXide DOT

Key Features

The DEKA SmartXide DOT stands out as a cutting-edge fractional CO2 laser machine. It’s packed with innovative features that make it a top choice for clinics offering advanced skin resurfacing treatments. This machine is the only CO2 laser that uses pulsed emission technology, ensuring precise and effective results.

Here’s what makes the DEKA SmartXide DOT unique:

SmartPulse Technology: Adjusts the dwell time (200 – 2000 µs) to control tissue coagulation, enhancing safety and precision.
SmartStack Technology: Delivers up to five pulses in a single spot, allowing deeper penetration while minimizing thermal damage.
DOT Pitch Customization: Offers spacing options from 200 to 2000 microns, making it adaptable for various skin types and conditions.
High Energy Tube: Provides over 200 watts of ablative power, outperforming many other lasers.
Pattern Variations: Includes 38 patterns via the Computer Pattern Generator (CPG), giving you flexibility in treatment approaches.
Delivery Modes: Features three CPG delivery modes designed to reduce patient discomfort during procedures.

These features make the DEKA SmartXide DOT a versatile and reliable option for clinics aiming to deliver the best one-time laser treatments.

Technical Specifications

The DEKA SmartXide DOT combines power and precision in its design. Here’s a quick overview of its technological innovations:

Feature	Description
High Energy Tube	Delivers over 200 watts of ablative power to tissue, more than other lasers.
SmartPulse	Controls coagulation of target tissue by adjusting dwell time (200 – 2000 µs).
DOT Pitch	Offers 200 – 2000 microns spacing when DOT mode is activated.
SmartStack	Allows up to 5 pulses into each spot in a single pass.
Pattern Variations	Provides 38 variations when using Computer Pattern Generator (CPG).
Delivery Modes	Includes 3 CPG delivery modes to minimize patient discomfort.

This machine’s advanced specifications ensure consistent results, whether you’re performing laser resurfacing or treating deeper skin concerns.

Applications

The DEKA SmartXide DOT is perfect for a wide range of skin resurfacing treatments. You can use it to address wrinkles, acne scars, and pigmentation issues. It’s also effective for improving skin texture and elasticity. The machine’s versatility extends to both superficial and deep resurfacing, making it suitable for various patient needs.

If you’re looking for a fractional CO2 laser machine for sale that delivers visible results with minimal downtime, this one is hard to beat. Patients love the smoother, rejuvenated skin they achieve after just one session.

Pros

Advanced fractional technology ensures precise treatments.
Customizable settings for tailored procedures.
Minimal downtime with faster recovery.
High energy output for effective skin resurfacing.
Versatile applications, from wrinkles to pigmentation.
Designed to enhance patient comfort during treatments.

The DEKA SmartXide DOT combines innovation and reliability, making it a valuable addition to any clinic. Its ability to deliver consistent results while prioritizing patient comfort sets it apart from other machines on the market.

Comparison Table of the Top 10 Machines

When you’re deciding on the best fractional CO2 laser machine, comparing key metrics can make your choice much easier. Here’s a breakdown of the most important factors to consider.

Key Metrics for Comparison

Price Range

Price is often the first thing you think about when buying a machine. These devices range from $20,000 to $100,000, depending on their features and capabilities. For example, the FotroMed CO₂ CeloLaser Compact offers excellent value for smaller clinics, while premium models like the DEKA SmartXide DOT come with advanced features that justify their higher price tag. Always weigh the cost against the machine’s lifespan and the potential revenue it can generate for your clinic.

Power and Performance

Power and performance directly impact the quality of your treatments. Machines like the FotroMed Fractional CO2 Laser Machine and the Lumenis AcuPulse deliver consistent energy output, ensuring precise and effective results. The DEKA SmartXide DOT stands out with its high energy tube, offering over 200 watts of ablative power. If you’re looking for versatility, the Syneron CO2RE’s dual laser modes let you treat both superficial and deep skin layers in one session.

Applications and Versatility

You want a machine that can handle a variety of treatments. The FotroMed CO₂ CeloLaser Pro excels in skin resurfacing, scar reduction, and wrinkle treatments. On the other hand, the Alma Pixel CO2 is perfect for improving skin elasticity and tone. Machines like the Cynosure SmartSkin+ and ActiveFX with UltraPulse Encore focus on quick recovery and minimal downtime, making them ideal for busy clinics. Versatility ensures you can meet the diverse needs of your clients.

User-Friendliness

A user-friendly interface can save you time and reduce the learning curve. The FotroMed CO₂ CeloLaser Pro features a 12.1-inch LCD screen for easy navigation. Similarly, the Lumenis AcuPulse and Cynosure SmartSkin+ offer intuitive controls that simplify operation. If you’re new to fractional lasers, these machines make it easy to deliver professional-grade results without extensive training.

Maintenance and Warranty

Maintenance and warranty are crucial for long-term reliability. Machines like the FotroMed Fractional CO2 Laser Machine come with refillable designs and long lifespans, reducing operational costs. Most devices, including the DEKA SmartXide DOT, offer comprehensive warranties and manufacturer support. Always check for maintenance requirements to avoid unexpected expenses.

Tip: Choose a machine that balances cost, performance, and versatility. This ensures you get the best results for your investment.

How to Choose the Right Fractional CO2 Laser Machine

Assessing Your Needs

Intended Applications

Before you invest in a fractional CO2 laser machine, think about how you’ll use it. Are you focusing on skin resurfacing, scar reduction, or wrinkle treatments? Each machine has unique strengths, so matching its capabilities to your clinic’s services is key.

Here’s a quick breakdown of factors to consider:

Factor	Description
Quality	Always check the quality of the machine to ensure it meets production standards.
Durability	Consider the durability to avoid frequent reinvestment in new equipment.
Ease of use	Ensure the machine is user-friendly, especially for beginners.
Cost	Compare prices from multiple manufacturers to find a cost-effective solution.

By evaluating these factors, you’ll ensure the machine aligns with your clinic’s goals and delivers the results your clients expect.

Budget Considerations

Your budget plays a big role in your decision. Machines range from affordable options to high-end models with advanced features. While it’s tempting to go for the cheapest option, remember that durability and performance matter. A slightly higher upfront cost can save you money in the long run by reducing maintenance and replacement expenses.

Evaluating Machine Features

Power and Precision

The power and precision of a machine determine the quality of your treatments. Advanced models, like the UltraPixel fractional CO2 laser, offer enhanced precision and multiple wavelengths for customized procedures.

Feature	Description
Enhanced Precision	The UltraPixel fractional CO2 laser machine offers unparalleled precision in treating skin issues.
Versatility	Capable of addressing various skin conditions, including wrinkles, scars, and pigmentation.
Multiple Wavelengths	Utilizes three combined wavelengths for improved treatment customization.
Advanced Applicators	Incorporates advanced applicators for tailored procedures.
Improved Patient Comfort	Features an advanced cooling system and large spot size for faster, more comfortable treatments.
Distinct Modes of Operation	Offers Single Pulse, Continuous Pulse, Repeated Pulse, and Ultra-pulse modes for various treatments.

Machines with these features ensure consistent results and a better experience for your clients.

Safety Features

Safety should always be a priority. Look for machines that comply with local safety regulations and include features like integrated cooling systems and energy tracking. These features protect both you and your clients during treatments.

Compliance with local safety and legal requirements
Integrated cooling capabilities
Energy tracking
Patient safety features

Choosing a machine with robust safety features minimizes risks and builds trust with your clients.

Considering Manufacturer Support

Warranty and Maintenance

A good warranty can save you from unexpected repair costs. Manufacturers like Fotromed offer refillable designs and long lifespans, reducing operational expenses. Some brands also provide customizable warranties and access to premium service providers for maintenance.

Training and Customer Support

Training and support are essential, especially if you’re new to fractional CO2 laser machines. Fotromed’s customer service team provides extensive training, marketing assistance, and a global maintenance policy. This ensures you’re confident in using the machine and delivering top-notch results.

Other manufacturers, like Oscilla Lasers, refurbish pre-owned systems and offer a network of service providers. This level of support ensures your machine stays in excellent condition, allowing you to focus on your clients.

Tip: Always choose a manufacturer that offers comprehensive training and reliable customer support. It makes a huge difference in your overall experience.

Choosing the right fractional CO2 laser machine can feel overwhelming, but it doesn’t have to be. Each of the top 10 machines we’ve covered offers unique features, from the compact design of the FotroMed CO₂ CeloLaser Compact to the high precision of the DEKA SmartXide DOT.

To make the best choice, align your decision with your clinic’s needs. Here’s a quick guide to help:

Factor	Description
Your budget	Find a machine that fits your budget without sacrificing quality.
Space limitations	Opt for compact models if your clinic has limited space.
User-friendliness	Choose a device that’s easy to operate and manage.
Compliance and safety	Ensure the machine meets local safety standards.

💡 Tip: Use the comparison table and buying guide to weigh your options. A well-informed choice ensures better results and happier clients!

FAQ

What is a fractional CO2 laser machine?

A fractional CO2 laser machine uses laser energy to create tiny, controlled injuries in the skin. These micro-injuries stimulate collagen production and promote skin healing. It’s a popular choice for treating wrinkles, scars, and uneven skin tone.

How does fractional CO2 laser treatment work?

The laser creates microscopic columns of heat in the skin, leaving surrounding tissue untouched. This triggers the body’s natural healing process, improving skin texture and elasticity. You’ll notice smoother, firmer skin after just a few sessions.

Is fractional CO2 laser treatment safe?

Yes, it’s safe when performed by trained professionals. Most machines, like those from FotroMed, are FDA-approved and include safety features like energy tracking and cooling systems to protect your skin during treatment.

How long is the recovery time after treatment?

Recovery typically takes 5-7 days. You might experience redness and mild swelling, similar to a sunburn. Most people return to their normal routine within a week. Always follow post-treatment care instructions for the best results.

Can all skin types benefit from fractional CO2 lasers?

Most skin types can benefit, but it’s best to consult a professional. They’ll assess your skin and recommend the right settings. Machines like the FotroMed CO₂ CeloLaser Pro offer customizable options to suit different skin tones and concerns.

How do I maintain my fractional CO2 laser machine?

Regular maintenance is key. Clean the handpieces after each use and follow the manufacturer’s guidelines for servicing. Many machines, like those from FotroMed, come with refillable designs and long lifespans, making upkeep easier.

What should I look for when buying a fractional CO2 laser machine?

Focus on power, precision, and versatility. Check for FDA or CE certifications, customizable settings, and a user-friendly interface. Also, consider the manufacturer’s support, like training and warranty options, to ensure a smooth experience.

Are fractional CO2 laser treatments painful?

Most treatments are tolerable. A numbing cream is usually applied beforehand to minimize discomfort. Some machines, like the DEKA SmartXide DOT, include cooling systems to enhance comfort during the procedure.

Tip: Always ask your provider about pain management options if you’re concerned.

Professional Fractional CO2 Laser For Sale:

CeloLaser CO2

CO₂ CeloLaser Pro

CO₂ CeloLaser Compact